Laser Triggered Nanoshells Deliver Drugs Inside Tumors

Researchers have developed a method for delivering cancer-killing drugs inside tumors with gold nanoparticles they can activate remotely using a laser. The researchers employed gold nanoshells to deliver toxic doses of two drugs — lapatinib and docetaxel — inside breast cancer cells, showing they could use a laser to remotely trigger the particles to release the drugs after they entered the cells. Though researchers conducted the tests with cell cultures in a lab, they designed the research to demonstrate clinical applicability: The nanoparticles are nontoxic, the drugs are widely used, and the low-power, infrared laser can non-invasively shine through tissue and reach tumors several inches below the skin. [Read More]