IBM DNA Sequencing Chip Uses Nanopores

Researchers at IBM are working on a chip for faster and less expensive DNA sequencing, drawing on the companys knowledge of semiconducter manufacturing technology. The chip controls the movement of individual DNA molecules through layered electrodes and uses a technique known as nanopore sequencing that promises to permit DNA to be passed through a sensor to read off its genetic code.

Nanopore sequencing, unlike currently used sequencing methods, would be able to read long stretches of DNA, eliminating the need for chopping and amplifying enzymes. Other research teams around the world are developing analogous approaches to nanopore sequencing. One of the impediments to creating a useful nanopore sequencer is the need to control the rate of the movement of the DNA through the pores. The IBM researchers are focusing on this problem.

For the past 2 years, a group at IBM has been developing chips with "DNA transistors" that have layered electrodes of about 3 nanometers thickness, to control the DNA movement. The electrodes are manufactured on IBMs research fab line with the same technology used to build silicon integrated circuits. If the chip proves to be successful it could enable a new era of personalized genetic medicine, the company said. The goal would be to map an individuals unique genetic sequence for a price of less than $1000. Within three years the team should know if their goal is feasible or not. Lets wish them success.